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马凡综合征中副脊髓肌肉体积减少和组成变化:一项回顾性队列研究
Yuichi Yoshida1, Toru Doi2, Hiroyuki Oka3
1Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Medicine
|September 29, 2023
概括
患有马方综合征 (MFS) 的患者表现出明显的脊柱形,原因是与异常脊柱形 (IS) 相比,脊柱肌的大小和功能减少. 这项研究发现MFS患者的肌肉截面面积较小,功能能力降低,这可能解释了他们独特的脊柱问题.
科学领域:
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 马芬综合征 (MFS) 中的脊柱形不同于异常学脊椎病 (IS),表现出更高的进展率和形位不整.
- 在MFS中这些明显的脊椎形的根本原因尚未完全理解.
研究的目的:
- 调查MFS患者脊柱肌肉结构的特征.
- 测试假设MFS患者的副脊髓肌肉与IS患者的副脊髓肌肉有数量或质量上的不同.
主要方法:
- 追溯队列研究比较17名MFS患者 (<25岁) 与年龄和性别匹配的IS患者进行脊柱结石手术.
- 术前T2加权的MRI用于测量L3/4和L4/5.5的psoas (PM) 和准脊椎肌肉 (PVM) 的相对横截面积 (rCSA),脂肪透率 (FI%) 和相对功能横截面积 (rFCSA).
主要成果:
- 与IS患者相比,MFS患者在L3/4和L4/5的PM的rCSA显著较小.
- 在MFS组中观察到L4/5的PM中的FI%更高.
- 与IS患者相比,在MFS患者中发现了PM (L3/4,L4/5) 和PVM (L3/4) 的显著较小的rFCSA.
结论:
- 马凡综合征患者的psoas肌肉的体型调整的横截面积减少,与异常脊椎病患者相比,psoas肌肉和准脊椎肌肉的体型调整的功能横截面积减少.
- 这些肌肉差异可能有助于在马方综合征中观察到的特征性脊柱形.
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