抗脂抗体携带者和患有静止抗脂综合征的患者表现出持续的亚临床补体激活
Margherita Zen1, Marta Tonello1, Maria Favaro1
1Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy.
Rheumatology (Oxford, England)
|September 29, 2023
概括
持久性抗脂抗体 (aPLs) 与正在进行的补充级联激活有关,即使在静止疾病阶段. 这种亚临床补充激活可能会导致aPL载体和APS患者的血栓形成风险.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 血液学 血液学 血液学
背景情况:
- 抗脂抗体 (aPLs) 与血栓形成的风险增加有关.
- 补充激活是aPL诱导的血栓形成的一个拟议机制.
- 在严重的抗脂综合征 (APS) 中观察到增强的补体激活,但其在静止疾病中的作用不太清楚.
研究的目的:
- 为了评估aPL阳性患者的补充激活,具有有利的疾病过程.
- 调查静止aPL阳性个体的补充激活和临床变量之间的关联.
主要方法:
- 招募的受试者包括aPL携带者,产科APS (OAPS) 患者和血栓性APS (TAPS) 患者,所有患者无症状≥2年.
- 为了进行比较,纳入了健康对照组.
- 使用ELISA测量C5a和C5b-9的血水平,并使用曼-惠特尼和斯皮尔曼相关性测试分析数据.
主要成果:
- 与健康对照组相比,静止的aPL阳性患者 (OAPS,TAPS,aPL携带者) 的血C5a和C5b-9水平明显较高.
- 在OAPS,TAPS患者和aPL携带者之间没有发现C5a和C5b-9水平的显著差异.
- 在C5b-9水平和阳性aPL测试数量之间观察到正相关性.
结论:
- aPL抗体的持久性与补充级联的持续亚临床激活有关.
- 这种持续的补充激活可能代表aPL阳性个体中血栓形成风险的生物标志物.
- 需要进一步的研究来阐明亚临床补充激活在aPL载体和APS患者中的临床影响.
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