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肠道向的纳米颗粒提供针对Clostridium perfringens感染的特别向的抗菌

Bocheng Xu¹, Weike Shaoyong¹, Lin Wang¹

¹National Engineering Research Center for Green Feed and Healthy Breeding, Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Institute of Feed Science, Zhejiang University, Hangzhou 310058, China.

Science advances

|September 29, 2023

概括

研究人员开发了针对肠道感染的新型抗微生物 (STAMP). 一个新的输送系统 (EPV@STAMP) 增强了对Clostridium perfringens的保护,有助于肠道微生物群的恢复.

科学领域:

微生物学微生物学
生物技术是生物技术.
药物发现药物发现药物发现

背景情况:

抗生素耐药性需要新的治疗策略.
开发针对结肠感染的向抗微生物药物在设计和交付方面面临挑战.
杆菌 (Clostridium perfringens) 是一种引起结肠疾病的重要病原体.

研究的目的:

为专门针对的抗微生物 (STAMPs) 制定一个高效的de novo设计策略.
为了确定有效对抗Clostridium perfringens的STAMP.
设计一个肠道向的输送系统,以提高STAMP在结肠感染中的有效性.

主要方法:

结合穿越设计,机器学习和菌体显示用于STAMP发现.
研究了STAMP的物理损伤,生物膜的消除,以及将其自组装成诱捕病原体的纳米粒子.
使用肠道向工程粒子疫苗 (EPV) 进行STAMP输送 (EPV@STAMP).

主要成果:

识别了具有物理抗微生物活性,生物膜根除和病原体捕获能力的STAMP.
与单独使用STAMP相比,EPV@STAMP在体内增强了对C. perfringens感染的疗效,并减少了炎症.
STAMPs和EPV@STAMP都促进了肠道微生物群的恢复.

结论:

开发的 de novo STAMP 设计策略对于发现新型抗菌素是有效的.
EPV@STAMP是一个有前途的平台,可以有针对性地向结肠提供抗菌药物.
这种方法加速了对结肠感染和肠道失生症的精确抗菌疗法的开发.

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