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Updated: Jul 15, 2025

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays
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Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays

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不匹配修复蛋白质缺乏不会影响I型子宫内膜癌的无疾病生存率

Yoan Alexandria Angelina1, Brahmana Askandar Tjokroprawiro1, Willy Sandhika2

  • 1Department of Obstetric & Gynaecology, Oncology Division, Airlangga University, Surabaya, Indonesia.

Asian Pacific journal of cancer prevention : APJCP
|September 29, 2023
PubMed
概括

不匹配修复缺陷 (dMMR) 的子宫内膜癌患者比熟练 (pMMR) 患者有更好的3年无病生存期 (DFS),尽管不显著. 瘤的阶段和等级是重复的关键预测因素.

关键词:
没有疾病的生存率.宫内膜癌 (Endometrial Carcinoma) 是一个体内膜癌.不匹配 维修 缺陷 缺陷

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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

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Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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