母亲衍生的抗体标位动态和住院婴儿登革热病风险
Megan O'Driscoll1, Darunee Buddhari2, Angkana T Huang1,2
1Department of Genetics, University of Cambridge, Cambridge CB23EH, United Kingdom.
概括
婴儿登革热疾病风险受到母亲抗体的影响. 抗体依赖增强 (ADE) 最好解释婴儿严重登革热,尽管出生率下降降了婴儿整体登革热风险.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 一岁以下的婴儿在流行地区面临高登革热病毒 (DENV) 感染率.
- 孕产妇产生的DENV抗体可以成为亚中和,通过抗体依赖增强 (ADE) 可能增强感染.
- 由于抗体动态和测量挑战,了解婴儿登革热风险是复杂的.
研究的目的:
- 分析DENV抗体数据和婴儿住院记录,以了解婴儿登革热疾病风险.
- 重建母体抗体动态,并探索与抗体相关的婴儿登革热风险增加的机制.
- 评估不断变化的登革热流行病学和出生率对婴儿登革热风险的影响.
主要方法:
- 分析了来自两个婴儿队伍 (142名婴儿,605名血液抽取) 的DENV抗体数据.
- 利用泰国的40年婴儿登革热住院数据.
- 数学建模用于重建母体抗体动态和评估ADE机制.
主要成果:
- 抗体依赖增强 (ADE) 机制最有效地解释了观察到的婴儿登革热住院数据.
- 泰国的出生率下降和登革热流行病学的转变使得婴儿登革热疾病的绝对风险在40年内减少了88%.
- 这些人口和流行病学变化对住院婴儿的平均年龄的影响很小.
结论:
- 母亲抗体和ADE在婴儿登革热病严重程度方面发挥着至关重要的作用.
- 虽然婴儿登革热的整体风险已经显著降低,但严重疾病的潜在机制仍然很重要.
- 公共卫生战略应考虑抗体动态和婴儿登革热管理的流行病学趋势.
相关概念视频
01:22Development of Immunocompetence
339
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
339
01:15Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K