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代表性 perfluoroalkyl 酸的发育毒性的显著变化作为化学特异的函数

Yachen Bai^1,2, Qi Wang³, Jing Li^1,2

¹Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

Environmental science & technology

|September 29, 2023

概括

化学形式对和多基物质 (PFAS) 毒性的重要性. 酸比盐更有毒,比盐更能积累,影响斑马鱼的发育和内分泌干扰.

科学领域:

环境毒理学环境毒理学
化学规格化学规格化学规格化学规格
发展生物学发展生物学

背景情况:

对于在相似的暴露条件下使用的 perfluoroalkyl 酸 (PFAA) 存在相互矛盾的毒理学数据.
了解化学形式对PFAA毒性的影响对于准确的风险评估至关重要.

研究的目的:

调查化学物种化 (酸与盐) 对代表性PFAA的发育毒性的影响.
探索毒性和内分泌干扰的机制.

主要方法:

斑马鱼胚胎对 perfluorooctanoic acid (PFOA), perfluorobutane carboxylic acid (PFBA), perfluorobutanesulfonic acid (PFBS) 和它们相应的盐的急性暴露.
发展障碍和甲状腺轴障碍的评估.
生物层干涉测量用于测量蛋白质与专蛋白的结合.

主要成果:

与它们的盐形式相比,PFAA酸在斑马鱼胚胎中显示出明显更高的毒性和发育障碍.
在PFAA酸和盐之间观察到明显的内分泌干扰模式.
PFAA酸在斑马鱼胚胎中表现出比它们的盐更强的蛋白结合和更高的积累.

结论:

酸的化学特异性极大地影响了它们的发育毒性和毒理学特征.
对PFAA的风险评估和管理策略必须区分酸和盐形式.

关键词:

结合专辑蛋白的结合.生物积累的生物积累化学物种的化学特征发展性毒性发展性毒性 perfluoroalkyl 酸的含量是什么甲状腺内分泌干扰甲状腺内分泌干扰

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