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镇痛剂低剂量胺注入对心血管反应的影响:回顾性分析
Adriana M Cadavid1, Fabian D Casas2, Julio E Camelo1
1Pain Medicine Unit Hospital Universitario San Vicente Fundación, Medellín, Colombia; Department of Anesthesia, University of Antioquia, Medellín, Colombia.
Pain physician
|September 29, 2023
概括
低剂量胺注入 (LDKI) 有效地管理急性疼痛,没有显著的心血管副作用. 这种阿片类药物节约方法对接受LDKI治疗手术和非手术疼痛的患者的血压和心率的影响最小.
科学领域:
- 麻醉学和疼痛管理
- 药理学 药理学是指药理学的学科.
- 心血管研究研究心血管研究
背景情况:
- 低剂量胺注入 (LDKI) 越来越多地被用作一种阿片类药物缓解剂,用于治疗急性疼痛的多模式止痛.
- 了解LDKI的心血管作用至关重要,因为胺胺已知有剂量依赖的心血管副作用.
- 这项研究调查了LDKI治疗急性疼痛患者的心血管反应.
研究的目的:
- 评估LDKI对急性疼痛患者血液动力学变量 (血压和心率) 的影响.
- 评估心理模拟效应作为次要目标.
- 确定LDKI在疼痛管理中的心血管安全概况.
主要方法:
- 对318名接受LDKI (0.1毫克/千克/小时) 治疗急性手术和非手术疼痛的成年患者进行了回顾性单中心队列研究.
- 基线,24小时和48小时测量静缩血压,静缩血压,平均动脉压和心率的比较.
- 排除患有先前精神病,心血管或认知疾病的患者;在clinicaltrials.gov (NCT03979105) 注册.
主要成果:
- 在基线和LDKI后治疗 (P <0.05) 之间没有观察到静脉血压,透气血压,平均动脉压或心率的统计学上显著差异.
- 血液动力学变量在患有高血压和没有高血压的患者之间没有显著差异.
- 严重疼痛的频率显著下降,观察到的心理效应 (混乱,幻觉,梦) 不常见. 没有发生重大心血管事件.
结论:
- 低剂量胺注入 (0.1 mg/kg/h) 在急性疼痛患者中不会导致血压或心率发生显著变化.
- 当LDKI作为多模式止痛药的辅助剂时,其对心血管系统的影响很小.
- 这些发现支持使用LDKI来治疗急性疼痛,具有良好的心血管安全概况.
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