旋转血栓形成仪凝血参数 (ROTEM®) 可能对活跃炎症性肠病产生歧视:一项前性观察性研究
Corina Meianu1, Stefan Andrei2, Mircea Diculescu3
1Department of Gastroenterology, Fundeni Clinical Institut, Bucharest, Romania; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania. corina_meianu@yahoo.com.
Journal of gastrointestinal and liver diseases : JGLD
|September 29, 2023
概括
旋转性血栓形成仪 (ROTEM®) 显示在活跃的炎症性肠病 (IBD) 中凝血发生变化. ROTEM®参数准确地预测活跃IBD,并与炎症标志物相关联,表明潜在的指导治疗.
科学领域:
- 凝血和血栓形成的原因
- 胃肠病学 胃肠病学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 炎症性肠病 (IBD) 与较高的血栓栓塞事件风险有关.
- 旋转性血栓形成显微镜 (ROTEM®) 是一种成熟的凝血评估工具.
- 在此之前,ROTEM®尚未在IBD患者中进行研究.
研究的目的:
- 研究ROTEM®在评估IBD患者凝血中的实用性.
- 为了确定ROTEM®参数是否可以预测活跃的IBD.
- 探索ROTEM®参数与IBD炎症标志物之间的相关性.
主要方法:
- 一项前性观察性研究,涉及成人IBD患者入院到国家高等医疗中心.
- 进行了ROTEM®分析 (INTEM,EXTEM,FIBTEM),评估了诸如凝血时间 (CT),凝血形成时间 (CFT) 和最大凝血牢固度 (MCF) 等参数.
- 用接收器操作特征 (ROC) 曲线来评估ROTEM®对活跃IBD的预测能力.
主要成果:
- 几个ROTEM®参数 (CT,CFT,A5,A10,MCF) 与缓解相比,与活性IBD有显著的关联,表明高凝血状态.
- 在预测活跃IBD时,ROC分析显示了对凝块强度参数 (A5,A10,MCF) 的高预测能力 (AUC>0.8).
- ROTEM®参数与诸如C反应蛋白 (CRP) 和便calprotectin (FC) 等炎症标志物有很强的相关性.
结论:
- 在活跃的IBD中,ROTEM®参数发生变化,与炎症相关.
- ROTEM®显示出对活跃IBD具有显著的预测能力.
- 需要进一步的研究来验证ROTEM®对区分IBD活动模式和指导抗凝剂治疗的有效性.
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