肝硬化患者再食低血的频率和相关危险因素:试点研究
Gulten Can Sezgin1, Nurhayat Tugra Ozer2, Gulsah Gunes Sahin3
1Department of Gastroenterology, Erciyes University, Faculty of Medicine, Kayseri, Turkey. gcsezgin@gmail.com.
Journal of gastrointestinal and liver diseases : JGLD
|September 29, 2023
概括
24%的肝硬化患者出现了再养的低酸血症,特别是那些接受肠道营养的患者. 在接受人工养的营养不良肝炎患者中,密切监测这种情况至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 临床营养学 临床营养学
背景情况:
- 再养低度血症 (RH) 与不良结果和死亡率有关.
- 肝硬化患者中RH的患病率尚未得到充分确立.
- 了解RH频率对于管理肝硬化患者至关重要.
研究的目的:
- 为了确定肝硬化患者再食低度 (RH) 的频率.
- 调查RH,营养状况和疾病严重程度之间的关系.
- 在这个人群中识别RH的风险因素.
主要方法:
- 在胃肠病诊所进行的前性单中心研究.
- 使用主观全球评估 (SGA) 评估的营养不良.
- 用儿童和MELD得分评估疾病严重程度;低酸血症定义为血清酸盐<2.0 mg/dl.
主要成果:
- 24% (12/50) 的肝硬化患者在住院期间发生了RH.
- 服用后4天RH最常见 (酸盐的中位数为2.3mg/dL).
- 亲肠道营养与较高的RH发病率相关 (p<0.05).
结论:
- 重新养的低脂血症影响大约四分之一的肝硬化患者.
- 人工营养,特别是肠外营养,对RH构成重大风险.
- 营养不良的肝硬化患者在腹腔营养需要密切监测RH.
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