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causalityCmprsk:一个R包用于非参数和基于Cox的平均治疗效应在竞争风险中的估计数据
Bella Vakulenko-Lagun1, Colin Magdamo2, Marie-Laure Charpignon3
1Department of Statistics, University of Haifa, Haifa, Israel.
Computer methods and programs in biomedicine
|September 29, 2023
概括
本研究介绍了causalCmprsk,这是一个R包,用于分析临床研究中的竞争风险数据. 它有助于准确估计治疗效果,避免因多种事件类型和混因素而产生偏差.
科学领域:
- 生物统计学 生物统计学
- 临床流行病学临床流行病学
- 因果推理因果推理
背景情况:
- 竞争的风险是常见的时间到事件的临床研究.
- 忽视竞争风险可能会导致偏见的结论.
- 混偏差必须在观察性治疗效应估计中加以解决.
研究的目的:
- 开发一个R包,causalCmprsk,用于在存在竞争性风险的情况下估计平均治疗效果.
- 提供用于对多个相互排斥的事件路径的时间到事件结果的因果分析工具.
主要方法:
- 实施逆概率权衡以模拟随机化并减少选择偏差.
- 适应现有的生存分析方法,用于非参数和半参数框架中的因果分析.
- 为各种目标人群提供不同的权重策略.
主要成果:
- 该包包括两个主要功能: `fit.cox` (半参数Cox模型) 和 `fit.nonpar` (非参数).
- 提供绝对风险 (累积发病率) 和相对治疗效应 (危险比率,受限平均时间差异) 的估计.
- 限制的平均时间差量化治疗效应在一个直观的时间域.
结论:
- 因果Cmprsk包是一个有价值的工具,用于对竞争风险数据的因果分析.
- 有助于区分后续终止的不同原因.
- 提供可访问的,随时间变化的治疗效果测量方法,并提供详细的文档.
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