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脂肪组织数量和分布对肥胖悖论在心力衰竭中的重要性
Saeid Mirzai1, Ian Persits2, Pieter Martens3
1Section on Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Internal Medicine.
The American journal of cardiology
|September 29, 2023
概括
心力衰竭 (HF) 中的"肥胖悖论"与皮下脂肪组织 (SATI) 有关. 较高的SATI,而不是内脏脂肪组织 (VATI),预测HF患者的生存率更好,独立于肌肉质量.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 医疗成像医学成像
背景情况:
- 肥胖是心力衰竭 (HF) 的危险因素之一.
- 矛盾的是,患有HF和肥胖症的患者表现得比较瘦的患者更好.
- 脂肪组织分布在HF预后中的作用尚未完全理解.
研究的目的:
- 研究脂肪组织数量和分布对急性不补偿性HF患者的结果的影响.
- 为了确定特定的脂肪储存 (内脏,皮下,心下) 是否会影响HF预后.
- 探索HF患者的身体组成和死亡率之间的关系.
主要方法:
- 对200名急性不补偿性HF入院患者的回顾性分析.
- 腹部/骨盆的计算机断层扫描 (CT) 用于测量内脏,皮下和肌肉间的脂肪组织和骨肌肉.
- 准心脏脂肪组织和腰围的测量;脂肪组织和骨肌肉的索引用于高度.
主要成果:
- 体重指数和腰围没有预测结果.
- 高皮下脂肪组织指数 (SATI) 与显著更好的生存率 (HR 0.58) 相关.
- 低内脏脂肪组织指数 (VATI) 和高SATI预测了最低的1年和4年死亡风险,独立于共变量.
结论:
- 这是一个很棒的节目,这是一个很棒的节目.
- 肥胖的悖论 肥胖的悖论
- 在心力衰竭中,似乎主要由皮下脂肪组织驱动.
- 皮下脂肪组织数量是改善HF患者生存率的重要预测因素.
- 脂肪组织分布,特别是较高的SATI,是肥胖HF患者观察到的改善预后的关键因素.
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