在产前症疾病中,LncRNAs,外体衍生MSC和免疫调节分子的功能
Sulieman Ibraheem Shelash Al-Hawary1, Nahla A Tayyib2, Pushpamala Ramaiah3
1Department of Business Administration, Business School, Al al-Bayt University, Mafraq, Jordan.
Pathology, research and practice
|September 29, 2023
概括
免疫信号通路的调节失调,如TIGIT和CTLA-4,以及P53和TIM,会影响正常的怀孕和健康. 本综述探讨了它们的作用和与疾病的联系,包括lncRNAs和干细胞.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 生殖生物学 生殖生物学
背景情况:
- 免疫调节途径,包括具有Ig和ITIM域的T细胞免疫受体 (TIGIT),细胞毒性T淋巴细胞相关蛋白4 (CTLA-4),P53信号传递,T细胞免疫球蛋白和粘素域 (TIM) 蛋白质,对于维持正常怀孕至关重要.
- 这些通路的失调或功能丧失可以导致各种妊娠并发症和其他疾病.
- 炎症是一种关键的免疫反应,涉及维持自我耐受性的细胞和分子信号机制.
研究的目的:
- 审查最近关于TIGIT,CTLA-4,P53和TIM调节分子作用的研究.
- 在各种疾病的背景下,研究这些关键通路的失调.
- 讨论长非编码RNAs (lncRNAs) 和介酶干细胞在免疫调节和疾病中的新兴作用.
主要方法:
- 对最近研究的文献综述,重点关注TIGIT,CTLA-4,P53和TIM信号.
- 分析研究,将途径失调与特定疾病联系起来.
- 探索研究研究 lncRNAs 和介酶干细胞的参与.
主要成果:
- 关键的免疫检查点TIGIT和CTLA-4,以及P53和TIM通路,对于怀孕期间的免疫耐受性至关重要.
- 这些通路中的异常信号与妊娠障碍和其他病理有关.
- lncRNAs和介酶干细胞成为影响免疫,新陈代谢和疾病发展的重要因素.
结论:
- 了解TIGIT,CTLA-4,P53和TIM的复杂作用对于理解正常怀孕和疾病发病是必不可少的.
- 对lncRNAs和介酶干细胞的进一步研究可能为免疫相关疾病提供新的治疗策略.
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