造成出血性中风的短期环境触发因素
Yuxin Guo1, Chun Luo1, Fang Cao1
1Department of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, Hunan 410078, China.
Ecotoxicology and environmental safety
|September 29, 2023
概括
短期环境触发因素,如空气污染 (PM2.5,SO2,NO2) 和极端天气增加了出血性中风的风险. 公共卫生战略应该减轻这些环境因素,以减少中风负担.
科学领域:
- 环境健康 环境健康
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 出血性中风 (HS) 具有显著的发病率和死亡率.
- 确定环境触发因素对于HS预防策略至关重要.
研究的目的:
- 评估短期环境触发因素 (STETs) 与出血性中风风险之间的关联.
- 综合现有关于空气污染物和气象因素作为HS风险因素的研究证据.
主要方法:
- 在六个数据库中进行系统的文献搜索,截至2022年9月9日.
- 使用随机效应模型进行元分析,以计算聚合赔率比率 (OR) 和95%置信区间 (CI).
- 使用Cochran Q和I2统计数据对异质性的评估.
主要成果:
- 对颗粒物2.5 (PM2.5),二氧化硫 (SO2) 和二氧化 (NO2) 的暴露显示出与增加HS风险的显著关联.
- PM2.5和SO2也与大脑内出血的风险有积极联系.
- 极端温度,高气压和高/低相对湿度被确定为潜在的HS风险因素.
结论:
- 空气污染物和恶劣的气象条件是导致出血性中风的短期环境触发因素.
- 建议针对环境暴露的公共卫生干预措施来减轻HS负担.
- 需要进一步的研究来证实这些与HS风险的环境关联.
相关概念视频
Vascular Spasm
1.5K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.5K
Introduction to Hemostasis
8.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.2K
Extrinsic and Intrinsic Pathways of Hemostasis
8.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
8.2K
Disorders of Hemostasis
982
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
982


