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多巴胺功能障碍:在新精神病学中遗传和表观遗传测试的作用
Kenneth Blum1, J Wesson Ashford2, Babak Kateb3
1Division of Addiction Research & Education, Center for Exercise, Sports and Mental Health, Western University Health Sciences, Pomona, CA, USA; The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX, USA; Department of Molecular Biology and Adelson School of Medicine, Ariel University, Ariel, Israel.
奖励缺陷综合征 (RDS) 治疗可以通过基因导向治疗来推进. 结合遗传上风险严重性 (GARS) 测试和KB220营养品,旨在恢复成的多巴胺平衡.
科学领域:
- 神经科学与遗传学
- 成研究 研究成研究
- 个性化医疗是个性化的医疗.
背景情况:
- 奖励缺陷综合症 (RDS) 是一个重要的全球健康问题,与成有关,造成了相当大的经济负担和死亡率.
- 非法物质的使用量正在上升,治疗差距很大,导致过量死亡人数增加.
- 目前的治疗方法是不够的,需要新的策略超越药品.
研究的目的:
- 提出一种替代的,非药物,基因导向的治疗方法来治疗奖励缺陷综合征.
- 探索大脑的奖励回路,神经递质缺陷和多巴胺平衡在成中的作用.
- 为推进RDS研究和治疗提出可操作的项目.
主要方法:
- 使用遗传上风险严重性 (GARS) 测试进行风险评估.
- 使用亲多巴胺调节剂营养药KB220促进多巴胺平衡.
- 专注于腹部体区域 - 体核 (VTA-NAc) 多巴胺通路.
主要成果:
- GARS和KB220的组合旨在在大脑的奖励回路中诱导多巴胺平衡.
- 这种方法针对RDS的潜在神经生理学,解决遗传和表观遗传的影响.
- 通过恢复神经化学平衡,有可能改善治疗结果.
结论:
- 倡导神经生理学上准确的诊断术语,而不是污名化的标签.
- 建议继续研究脑干神经递质功能障碍和早期风险识别.
- 支持精确行为管理,GARS,KB220变体以及用于RDS的TMS和DBS等神经调节疗法.
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