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关于EWGSOP1和EWGSOP2可能的肉症定义与死亡率的关联:一项比较研究
Mustafa Altinkaynak1, Erdem Gurel1, Meryem Merve Oren2
1Department of Internal Medicine, Division of General Internal Medicine, Istanbul Medical School, Istanbul University, Fatih, 34390, Istanbul, Turkey.
Clinical nutrition (Edinburgh, Scotland)
|September 29, 2023
概括
另一种类型的肉症定义对老年人死亡风险产生影响. 针对可能的肉症 (肌肉损失的情况) 使用特定人群的切断值与增加的死亡风险有关.
科学领域:
- 老年学是一门学科.
- 老年医学 老年医学
- 流行病学 流行病学
背景情况:
- 萨科佩尼亚是一种与残疾和死亡率相关的重大老年综合征.
- 了解它对社区老年人的影响对于公共卫生至关重要.
- 为了准确的风险评估,研究不同类型的肉类的诊断标准至关重要.
研究的目的:
- 检查不同类型的肉症定义与老年人死亡率之间的关联.
- 为了比较不同手握强度 (HGS) 切线在萨尔科佩尼亚诊断标准中的预测值.
- 为了确定人群特异性HGS切割线是否与标准切割线相比,改善死亡风险预测.
主要方法:
- 使用欧洲老年人肉症工作组 (EWGSOP1和EWGSOP2) 标准定义了肉症.
- 手握强度 (HGS) 的截止值包括标准值 (EWGSOP1: 30/20 公斤; EWGSOP2: 27/16 公斤) 和特定人群值 (EWGSOP2: 35/20 公斤).
- 评估了五年死亡率,并进行了考克斯回归分析,调整了年龄和肉症的定义.
主要成果:
- 根据定义,肉症的患病率有很大的差异:4.9% (EWGSOP1),23.5% (EWGSOP2标准),和50.0% (EWGSOP2特定于人群).
- 根据EWGSOP1的定义 (HR=4.26) 和EWGSOP2以特定人群的截止值 (HR=2.58) 与增加5年死亡风险显著相关.
- 使用标准切断值的EWGSOP2可能的肉类没有显示出与死亡率的显著关联 (p=0.09).
结论:
- 这项研究是第一个比较EWGSOP2定义的可能的肉病死亡风险,使用标准与人口特定的HGS截止值.
- 结果表明,特定人群的HGS切断值与老年人死亡风险的关系更强.
- 这些发现对全球社区居住的老年人群中 Sarcopenia 的诊断和管理有意义.
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