父母抑郁和焦虑症状严重程度及其后代皮质厚度和皮质下体积之间的关联
Jennifer Kemp1, Sneha Chenji2, Frank MacMaster3
1Department of Psychiatry, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Calgary, AB, Canada; Mathison Centre for Mental Health Research & Education, Calgary, AB, Canada.
Journal of psychiatric research
|September 29, 2023
概括
父母抑郁症的严重程度与青少年后代的表面积减少有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 父母的精神病理可能会影响后代的大脑发育.
- 之前的研究表明,抑郁症/焦虑症和青春期灰质变化之间存在关联.
- 父母症状严重程度与后代大脑结构之间的关系需要进一步研究.
研究的目的:
- 调查父母抑郁和焦虑症状严重程度与后代大脑结构之间的关联.
- 为了确定家长心理病理的严重程度是否影响青少年的皮质和皮质下大脑区域.
- 确定青少年情绪障碍风险的潜在早期生物标志物.
主要方法:
- 123名青少年 (平均年龄13.64岁) 的父母被诊断患有抑郁症或焦虑症.
- 通过迷你国际神经精神病学面试评估父母的诊断状态.
- 使用贝克抑郁 inventory-II和通用焦虑障碍-7.7测量的父母症状严重程度.
- 使用T1加权结构磁共振成像分析青少年大脑结构.
主要成果:
- 父母焦虑的严重程度与后代的左侧全球表面积减少有关.
- 后代的右侧表面积显示出与父母抑郁症严重程度的负面关联的趋势.
- 在以前抑郁的父母中,父母抑郁症的严重程度更高与左和右后代表面积的减少有关.
结论:
- 父母抑郁症状的严重程度与青少年皮质表面积的改变有关.
- 这些发现可能有助于识别有情绪障碍风险的年轻人.
- 这项研究支持对处于危险的年轻人的早期干预和识别工作.
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