用于提高药物封装和释放效率的奇托/PEGDA生物纳米复合物的制造
Raquel de Castro1, Gurshagan Kandhola2,3, Jin-Woo Kim2,3,4
1Department of Chemical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Molecular pharmaceutics
|September 29, 2023
概括
这项研究开发了新型的基托桑颗粒和复合膜,用于胺药物输送. 聚乙烯甘醇) 二烯酸盐增强了封装和颗粒均性,而不妨碍释放.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 药物输送系统 (DDS) 面临着系统吸收和低生物可用性等挑战.
- 基托 (Cs) 颗粒和水凝被探索为目标的DDS.
- 封装效率和受控释放仍然是关键障碍.
研究的目的:
- 开发素颗粒 (CsP) 和复合膜,用于胺素 (GtS) 封装和输送.
- 研究聚乙烯甘二烯酸盐 (PEGDA) 在增强CSP中的作用.
- 为控制药物释放创建一个交叉链接的膜系统.
主要方法:
- 制造CsP和Cs-PEGDA复合薄膜. 这些产品包括:
- 在CSP中封装 gentamicin (GtS).
- 对酶介导的GtS释放机制的评估.
- 评估PEGDA对封装效率和颗粒性质的影响.
- 使用迈克尔的反应形成膜的交叉链接CSP和PEGDA.
主要成果:
- 通过减轻Cs和GtS之间的电荷排斥,PEGDA提高了GtS封装效率.
- PEGDA 提高了颗粒的均性,而不会阻碍溶酶诱导的降解.
- Cs-PEGDA复合膜有效地定了CSP,防止了GtS过早释放.
- 莱索酶成功降解了奇托,从颗粒和膜中释放了活性GtS.
结论:
- 素颗粒和PEGDA复合膜为增强药物输送提供了一个有希望的方法.
- PEGDA 提高了基托基DDS中的封装效率和颗粒特征.
- 开发的薄膜系统提供了 Gentamicin 的受控释放,保持其活性.
相关概念视频
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...


