抗抑郁药和抗精神病药的副作用和个性化处方:系统性审查和数字工具开发
Toby Pillinger1, Oliver D Howes1, Christoph U Correll2
1Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Imperial College London, London, UK.
The lancet. Psychiatry
|September 29, 2023
概括
这项研究创建了抗抑郁药和抗精神病药副作用的综合数据库和一个数字工具,以帮助个性化精神病药物选择,旨在改善患者的治疗结果和治疗一致性.
科学领域:
- 精神病学和药理学 精神病学和药理学
- 临床决策支持系统 临床决策支持系统
- 基于证据的医学基于证据的医学.
背景情况:
- 精神病药物的副作用会对患者的生活质量,功能和治疗坚持产生负面影响.
- 现有的指南建议讨论副作用,但缺乏综合的资源.
- 对临床医生来说,管理复杂的,多维的副作用概况是具有挑战性的.
研究的目的:
- 开发抗精神病和抗抑郁药副作用的全面数据库.
- 创建一个数字工具,以帮助导航这些副作用数据库.
- 支持个性化,基于证据的精神病治疗决策.
主要方法:
- 进行了对Embase,PsycINFO和MEDLINE的元分析的综合审查.
- 收集了32种抗精神病药 (14种副作用) 和37种抗抑郁药 (9种副作用) 的数据.
- 使用多标准决策分析 (TOPSIS) 开发了一个名为Psymatik Treatment Optimizer的数字工具.
主要成果:
- 数据库包括来自68个元分析和19个指南的数据.
- 该工具将用户定义的副作用问题与编译的数据进行合成.
- Psymatik根据个体患者的偏好对治疗进行排名,有助于复杂的权衡.
结论:
- 开发的数据库和数字工具支持协作,个性化的处方.
- 这种方法与治疗抑郁症和精神分裂症的国际监管指南保持一致.
- 该工具对改善精神病学实践和患者治疗结果充满希望.
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