关于质量吸收曲线的模两可的性质
1Institute of Experimental Physics, Faculty of Mathematics, Physics and Informatics, University of Gdańsk, Wita Stwosza 57, 80-308 Gdańsk, Poland.
International journal of pharmaceutics
|September 29, 2023
概括
影声学揭示了通过皮肤递送药物的模式中的差异. 质量吸收 (m(t)) 数据与扩散模型保持一致,但度分布 (c(x,t)) 数据表明显著的界面转移,质疑标准分析方法.
科学领域:
- 药理动力学和药物输送方法
- 材料科学与工程 材料科学与工程
- 分析化学 分析化学
背景情况:
- 透皮药物递送系统 (TDDS) 依赖于了解通过膜的药物运输.
- 光声学提供了监测质量吸收 (m,t) 和度分布 (c,x,t) 的双重模式.
- 标准扩散模型 (Fickian) 通常用于分析TDDS中的药物运输.
研究的目的:
- 在一个模型透皮系统中研究光声学的相互矛盾的实验结果.
- 为了评估标准质量运输参数分析的可靠性,使用m (t) 和c (x,t) 数据.
- 阐明接口和散装运输对总体质量转移效率的贡献.
主要方法:
- 在药物供体/接受体膜系统中使用了两种光声学模式来测量总质量吸收 (m ⋅ t) 和时间依赖的度分布 (c ⋅ x,t).
- 应用了一个标准的Fickian扩散模型,具有恒定的源边界条件来分析m(t) 数据.
- 引入了一种新的运输率数参数,用于对c(x,t) 数据的详细分析.
主要成果:
- 测量的m (t) 数据与标准的Fickian扩散模型有很好的一致性.
- 标准分析方法对c(x,t) 数据失败,表明建模的局限性.
- 分析显示,界面传输对质量传输有着显著的贡献,几乎与散装运输相等.
- 导出无模型的特征时间,独立于特定的运输模型.
结论:
- 仅仅对m{\displaystyle m} ,t{\displaystyle t} 的数据进行标准分析,对于在TDDS中量化大众运输参数可能是不可靠的.
- 接口传输在药物透中起着至关重要的作用,必须在TDDS建模中考虑.
- 开发的传输速率数和无模型的特征时间为了解透皮传输动态提供了更全面的方法.
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