在COVID-19后出现新发喘的风险增加:全国范围的人口基队列研究
Bo-Guen Kim1, Hyun Lee1, Sang Woo Yeom2
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
The journal of allergy and clinical immunology. In practice
|September 29, 2023
概括
冠状病毒疾病 (COVID-19) 显著增加了新发喘的风险. 接种COVID-19疫苗可能有助于预防这种增加的风险,特别是在完全接种疫苗的个体中.
科学领域:
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
背景情况:
- 以前的研究将呼吸道感染与新发性喘联系在一起.
- COVID-19和新发喘风险之间的关联仍然不确定.
研究的目的:
- 为了确定最近的COVID-19感染是否会增加患上新发喘的风险.
- 调查COVID-19疫苗接种是否可以减轻这种潜在风险.
主要方法:
- 利用韩国国家医疗保险索赔数据库为三个不同的研究设计.
- 将COVID-19诊断的队列和接种疫苗的队列与匹配的对照进行了比较.
- 用员工调整的危险比率 (aHR) 来评估风险,控制潜在的混因素.
主要成果:
- 诊断COVID-19与新发喘风险增加2.14倍相关 (aHR 2.14).
- 接种COVID-19疫苗显示,新发喘的风险降低 (aHR为0.82).
- 在没有先前COVID-19诊断的人群中,疫苗的保护作用并不明显 (aHR 0.95).
- 亚组分析表明,完全接种疫苗的个体的风险较低,老年人和糖尿病患者的风险更高.
结论:
- COVID-19 感染与较高的新发喘发病率有关.
- 接种COVID-19疫苗似乎是一种潜在的预防措施,可以预防COVID-19相关的新发喘.
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