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Updated: Jul 15, 2025

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
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卡斯巴-3 分裂的会通过打开线粒体透性过渡孔损害线粒体功能

María José Pérez1, Rodrigo Ibarra-García-Padilla1, Maoping Tang2

  • 1Laboratory of Neurodegenerative Diseases, Centro de Investigaciones Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.

Biochimica et biophysica acta. Molecular basis of disease
|September 29, 2023
PubMed
概括

阿尔茨海默病 (AD) 中的线粒体功能障碍与caspase-3分裂的tau有关. 这种tau形式激活了线粒体透性过渡孔 (mPTP),导致神经元损伤. 抑制mPTP或去除环素D (CypD) 可以防止这些效应.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.环素 D D 环素 D线粒体中的线粒体.线粒体的透孔是线粒体的透孔.塔乌·塔乌 (Tau Tau) 是一个

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