乙醇配对条件刺激对乙醇反应的影响,乙醇被条件味道厌恶抑制
R J Lamb1, C W Schindler2, Brett C Ginsburg1
1Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
Alcohol (Fayetteville, N.Y.)
|September 29, 2023
概括
条件刺激 (CS) 可以增加乙醇摄入量,即使存在厌恶. 这项研究表明,光线提示信号乙醇安全性,当厌恶被抑制时,增加消费.
科学领域:
- 行为神经科学 行为神经科学
- 成的动物模型成的动物模型
- 学习和记忆的学习和记忆
背景情况:
- 已知有条件刺激 (CS) 会增加乙醇反应,特别是当反应较低时.
- 有条件的味道厌恶 (CTA) 通过改变其感知值来抑制乙醇摄入.
- 在乙醇反应中CS诱导的增加的普遍性,特别是在厌恶下,需要进一步调查.
研究的目的:
- 为了确定一个CS是否可以增加由CTA抑制的乙醇反应.
- 探索CS诱导的乙醇摄入量增加的潜在机制.
- 调查一下CS是否能传达安全信号,防止产生不良后果.
主要方法:
- 在随机间隔 (RI) 计划下,老鼠被训练以对乙醇做出反应.
- 刺激光 (CS) 与乙醇输送配对,并使用LiCl诱导CTA.
- 在不同的实验小组中,在CS介绍期间的响应与在没有CS时的响应进行了比较.
主要成果:
- 在所有组中,乙醇反应部分恢复,并且在光线呈现期间明显高于之前的时期.
- 在CS期间响应的增加在各组之间没有可靠的差异,这挑战了基于动机的解释.
- 结果表明,CS可能表明安全从厌恶的后果,而不是仅仅增加动机.
结论:
- 以前与乙醇输送配对的刺激光可以增加响应,即使被CTA抑制.
- 这些发现表明,CS可能会获得安全信号功能,表明乙醇是安全的消费.
- 这挑战了对CS引起的乙醇摄入量增加的纯粹动机或基于方法的解释.
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