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新型色素向的仿真抗原受体修饰的UNKT细胞在抑制瘤进展方面非常有效

Wei Jiang¹, Guosheng Gu², Yumin Zhang¹

¹Biotherapy Center, Harbin Medical University Cancer Hospital, Harbin 150081, China.

Pharmacological research

|September 29, 2023

概括

这项研究引入了通用自然杀手类T (UNKT) 细胞作为固体瘤的新型细胞免疫疗法. 这些工程UNKT细胞表现出强大的向瘤杀伤能力,提供了一个有前途的新治疗方案.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞疗法细胞疗法

背景情况:

化学抗原受体 (CAR) T细胞疗法在血液癌症中取得了成功,但在固体瘤中面临挑战.
现有的采用性免疫疗法与固体瘤微环境和非目标效应作斗争.

研究的目的:

开发和评估一种新的通用自然杀手类T (UNKT) 细胞系,用于固体瘤治疗.
评估针对美索林 (MSLN) 的CAR修饰的UNKT细胞对抗MSLN阳性固体瘤的疗效.

主要方法:

开发一种具有固有的细胞毒性和低移植对宿主活性的通用NKT (UNKT) 细胞系.
工程UNKT细胞与CAR准中素 (MSLN) 增强特异性.
在体外和体内测试使用3D有机体模型和卵巢癌的小鼠模型.

主要成果:

UNKT细胞对15个癌细胞系表现出广泛的细胞毒性,同时不影响正常细胞.
与野生型UNKT和MSLN-CAR-T细胞相比,MSLN-CAR-UNKT细胞对MSLN阳性卵巢癌细胞的杀死能力更强.
CAR-UNKT细胞在体内表现出增强的效应细胞因子 (氨酸,大酶B) 生产和强大的抗瘤活性,具有瘤透和迁移能力.

结论:

工程CAR-UNKT细胞代表了对固体瘤,特别是MSLN阳性癌症的有前途的细胞免疫疗法策略.
CAR-UNKT细胞提供了增强的多功能性和强大的抗瘤作用,表明了超越CAR-T细胞的新治疗选择.

关键词:

在CART-T中,我们可以使用CAR-T.细胞免疫疗法细胞免疫疗法化学抗原受体的化学抗原受体梅索他林是其中一种.在 NKT NKT 中.

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