相关实验视频

Updated: Jul 15, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

癌症研究中USP7互动组的当前和未来方向

Hong-Beom Park¹, Kwang-Hyun Baek²

¹Department of Convergence, CHA University, Gyeonggi-Do 13488, Republic of Korea.

Biochimica et biophysica acta. Reviews on cancer

|September 29, 2023

概括

无素-蛋白酶体系统调节蛋白质的稳态. 本综述详细介绍了全方位素特异性蛋白酶7 (USP7) 基质和癌症中的功能,并确定了治疗策略的潜在新点.

科学领域:

分子生物学分子生物学
生物化学生物化学
在瘤学瘤学.

背景情况:

无素-蛋白酶体系统 (UPS) 对于蛋白质稳态和自至关重要.
通过E1,E2和E3酶介导的ubiquitination修饰蛋白质,而通过DUBs的deubiquitination可以逆转这种情况.
这些酶的失调,特别是USP7,与癌症等人类疾病有关.

研究的目的:

审查USP7在癌症发病过程中的已知基质和细胞功能.
通过对其结合基因的系统分析,识别潜在的新型USP7基质.
为未来的研究和治疗开发提供有关USP7在癌症中的作用的见解.

主要方法:

关于USP7基质和功能的文献综述.
对USP7结合基因 ([P/A/E]-X-X-S或K-X-X-X-K) 的分析,以确定潜在的基质.
对蛋白质数据库和文献进行系统分析,以预测新的USP7相互作用.

主要成果:

一个关键的DUB,USP7,与许多参与癌症的基质相互作用.
最近通过动机分析确定了USP7的新型基质.
该审查总结了已建立的USP7基板,并提出了新的假定基板.

结论:

通过其多样化的基质相互作用,USP7在癌症发病过程中发挥着重要作用.
了解USP7的基质谱对于开发向癌症疗法至关重要.
对USP7新型基质的进一步研究可能会揭示新的治疗途径.

关键词:

有约束力的图案是有约束力的.生物信息学是一种生物信息学.消灭城市的消灭.基质基质是一种基质.乌比基特异性蛋白酶 7 是一种乌比基特异性蛋白酶.

更多相关视频

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

相关概念视频

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...