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功能性大脑网络的模块连接异常和抗-N-甲基-D-酸盐受体脑炎患者的认知变化

Dongying Huang¹, Caitiao Lv¹, Zexiang Chen¹

¹Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

|September 29, 2023

概括

患有抗NMDAR脑炎 (ANMDARE) 的患者表现出大脑功能网络的改变,在某些大脑模块内增强了连接. 大脑连接的这些变化可能是ANMDARE的认知缺陷的基础.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
系统生物学系统生物学

背景情况:

抗NMDAR脑炎 (ANMDARE) 是一种与显著的认知和精神症状相关的自身免疫性疾病.
了解ANMDARE认知功能障碍的神经基础对于开发向疗法至关重要.

研究的目的:

调查ANMDARE患者大脑功能网络的变化.
在ANMDARE中探索脑内模块和间模块连接和认知功能之间的关系.

主要方法:

分析了30名ANMDARE患者和30名健康对照者的休息状态功能性MRI (rs-fMRI) 数据.
建立了大脑功能矩阵,以评估模块内部和模块之间的功能连接 (FC).
计算了全脑功能拓和参与系数 (PC).

主要成果:

与HCs相比,ANMDARE患者在尾 - 尾 - 尾和副海马区域表现出增强的内部模块FC.
在特定的大脑区域观察到模块间连接的显著差异,由改变的参与系数表明.
没有发现全球拓性质或与认知/情感尺度的相关性有显著差异.

结论:

ANMDARE的特点是增强的内部模块功能连接和改变的模块间大脑网络组织.
这些发现为ANMDARE的认知变化背后的病理生理机制提供了全球网络视角.

关键词:

反N-甲基-D-酸盐受体脑炎功能连接功能连接图形理论是指图形的理论.模块化是一种模块化.

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