多种细菌培养的阳性反映了Mycobacterium avium复杂肺部疾病中的支气管切除症的严重程度和预后
Masashi Ito1, Koji Furuuchi2, Keiji Fujiwara2
1Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
Respiratory medicine
|September 29, 2023
概括
在诊断时患有Mycobacterium avium复杂肺病 (MAC-PD) 患者的细菌共感染与较低的治疗开始和增加支气管切除症恶化有关. 这一发现影响了MAC-PD的临床管理策略.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 在Mycobacterium avium复杂肺病 (MAC-PD) 中,细菌共感染很常见,影响了19-66%的患者.
- 在MAC-PD诊断时,细菌共感染的临床影响仍未得到充分研究.
研究的目的:
- 调查诊断时的细菌共感染与MAC-PD的临床过程之间的关联.
- 为了比较MAC-PD患者的特征和疾病进展,有和没有持久的细菌培养.
主要方法:
- 对218名MAC-PD患者的回顾性分析,这些患者在2016年至2020年期间被诊断出有连续唾液培养.
- 患者组的比较:特定细菌物种的细菌培养阳性 (BCP) 与细菌培养负 (BCN).
主要成果:
- BCP组 (n=70) 显示与高修改的雷夫分数相关.
- 在BCP患者中,MAC-PD治疗启动率较低 (41.4%vs. 67.6%) 和第一个支气管切除症恶化时间较短.
- 在BCP患者中,支气管切除症的恶化更频繁.
结论:
- 在MAC-PD诊断时的细菌共感染与治疗开始的减少有关.
- 在诊断时具有细菌共感染的患者有更高的风险发展支气管病变恶化.
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