相关实验视频

Updated: Jul 15, 2025

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
11:37

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution

Published on: February 26, 2019

9.8K

基准测试深度学习方法用于预测CRISPR/Cas9 sgRNA在目标上和目标之外的活动.

Guishan Zhang1, Ye Luo1, Xianhua Dai2,3

  • 1College of Engineering, Shantou University, Shantou 515063, China.

Briefings in bioinformatics
|September 29, 2023
PubMed
概括

深度学习模型擅长预测CRISPR/Cas9单向导RNA (sgRNA) 在目标上和目标之外的编辑,特别是在较大的数据集中. 在非目标预测的不平衡数据集上的性能需要进一步改进.

关键词:
这就是CRISPR/Cas9的作用.深度学习是一种深度学习.远离目标 - 远离目标在目标上 - 在目标上.sgRNARNA 是一个

更多相关视频

CIRCLE-Seq for Interrogation of Off-Target Gene Editing08:23

CIRCLE-Seq for Interrogation of Off-Target Gene Editing

Published on: November 1, 2024

678
In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

1.5K

相关概念视频

CRISPR and crRNAs02:53

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.1K