在现实环境中评估多发性硬化症口服药物的治疗反应:MAGNIMS研究
Serena Ruggieri1,2, Luca Prosperini1, Sarmad Al-Araji3
1Department of Neurosciences, San Camillo Forlanini Hospital, Rome, Italy.
Journal of neurology, neurosurgery, and psychiatry
|September 29, 2023
概括
评估复发性复发性多发性硬化症 (RRMS) 活动的MAGNIMS评分有效预测口服疾病修饰疗法 (DMT) 患者的结果. 早期复发和第一年的MRI活动表明结果更差.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 临床试验 临床试验
背景情况:
- 评估治疗反应对于在疾病修饰疗法 (DMT) 上复发性复发性多发性硬化症 (RRMS) 患者至关重要.
- MAGNIMS (多发性硬化症MRI) 网络开发了一种可注射DMT的评分系统.
- 这项研究研究了MAGNIMS评分对口服DMT的适应性.
研究的目的:
- 评估MAGNIMS评分,最初用于注射性DMT,是否可以预测口服DMT的患者的治疗反应.
- 评估口服DMT治疗RRMS患者1年MAGNIMS得分和3年结果之间的关联.
主要方法:
- 分析了1200名口服DMT (fingolimod, teriflunomide, dimethyl fumarate) 的患者的多中心数据集.
- 结合复发和新的T2病变的MAGNIMS得分,在1年后计算出来.
- 研究了与3年结果 (确认残疾恶化,治疗失败,复发数) 的关联,包括病变位置和对比增强病变 (CEL).
主要成果:
- 一年高的MAGNIMS得分与3年确认的残疾恶化 (CDW) 风险增加相关.
- 获得"1"分的患者的CDWHR是1.82倍,获得"2"分的患者的HR是2.74倍,而得分为"0".
- 结合病变位置和CEL,在MRI活动最小的患者中,改善了CDW和治疗失败的预测准确性.
结论:
- 在口服DMT治疗的第一年内,早期复发和显著的MRI活动与RRMS的短期结果较差有关.
- 马格尼姆斯得分证明了在预测口服DMT治疗反应方面的有用性.
- 损伤特征为治疗结果提供了额外的预测价值.
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