多环芳生物标志物的对心血管疾病的影响
Nie Qigang1, Arghavan Afra2, Andrés Alexis Ramírez-Coronel3,4
1Physician Department of the Health Team of the 32152 Army of the Chinese People's Liberation Army, The Health Team of the 32152 Army of the Chinese People's Liberation Army, Army Medical University, Chongqing, China.
多环芳 (PAH) 及其生物标志物与心血管疾病风险增加有关. 吸烟和排放的暴露会提高血压,心率和动脉样硬化,需要严格控制PAH来源.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管医学 心血管医学
背景情况:
- 多环芳 (PAH) 是由于有机物不完全燃烧而产生的环境污染物,有助于颗粒物.
- PAHs与通过氧化应激,炎症和动脉样硬化等机制增加心血管疾病 (CVD) 风险有关.
- 生物标志物是生物过程和疾病状态的关键指标,包括受PAH暴露影响的生物.
研究的目的:
- 评估多环芳 (PAH) 生物标志物对心血管疾病 (CVD) 的健康影响.
- 综合有关PAH暴露,其代谢物和心血管健康结果之间的关系的当前知识.
- 确定关键的PAH生物标志物及其与特定心血管并发症的关联.
主要方法:
- 采用了一个叙事审查方法,从Scopus,PubMed,Web of Science和Google Scholar (1975-2023) 收集数据.
- 选和选择过程包括有关PAHs和CVD的相关文章,并补充了参考清单审查.
- 分析的重点是确定PAH代谢物,其检测生物标志物和相关的心血管影响.
主要成果:
- PAHs的生物转化产生代谢物,如,二醇,和环氧化物,其中同位素是最常见的.
- 关键的生物标志物包括2-OHNAP (纳),3-OHPHEN (),2-OHFLU () 和1-OHPYR ().
- 暴露于PAH代谢物会提高血压,心率,促进动脉样硬化,并增加同型半素,胆固醇,高密度胆固醇,低密度胆固醇,C反应蛋白和甘油三.
结论:
- 来自吸烟,车辆排放和职业环境等来源的PAH生物标志物的暴露显著增加了心血管疾病的风险.
- 通过各种生化和生理途径,PAH暴露会导致不良的心血管结果.
- 严格控制PAH来源和暴露的实施对于减轻公共卫生风险至关重要.
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