肠道运动模式与认知功能之间的关联:前性队列研究和肠道微生物组的元基因组分析
Chaoran Ma1, Yanping Li2, Zhendong Mei2
1From the Channing Division of Network Medicine (C.M., Z.M., J.H.K., A.A., M.J.S., D.D.W.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Nutrition (C.M.), University of Massachusetts Amherst; Departments of Nutrition (Y.L., A.A., W.C.W., M.J.S., D.D.W.), Epidemiology (A.A., W.C.W., A.T.C., M.J.S.), and Biostatistics (C.H.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Medicine (C.Y.), Zhejiang University, Hangzhou, China; Rush Alzheimer's Disease Center (F.G.), Rush University Medical Center, Chicago, IL; Division of Gastroenterology (A.T.C.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Broad Institute of MIT and Harvard (A.T.C., C.H., D.D.W), Cambridge, MA.. dow471@mail.harvard.edu.
不频繁排便 (BM) 与健康成年人的认知功能较差有关. 肠道微生物组的变化可能解释了这种联系,突出了潜在的肠-大脑轴对认知的影响.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 在健康个体中,肠道运动性和认知功能之间的关系还不太清楚.
- 肠道微生物组是这种联系的潜在媒介.
研究的目的:
- 调查肠道运动 (BM) 模式与认知功能之间的关联.
- 探索肠道微生物组在调解这种关系中的作用.
主要方法:
- 对3项大型队列研究 (NHS,NHSII,HPFS) 的前性分析,涉及超过112,000名参与者.
- 通过神经心理测试对BM频率,主观认知功能和客观认知功能进行评估.
- 全基因组射击枪元基因组学,以对参与者的子集中肠道微生物组进行分析.
主要成果:
- 较低的BM频率 (每3天以上一次) 与较差的客观认知功能有显著的关联,相当于3.0年的加速认知衰老.
- 脑膜炎的频率显示出一个J形的剂量反应关系,主观认知衰退和投诉.
- 肠道微生物组的变化,包括生产丁酸盐的物种的减少和增加的促炎性物种,与BM频率和认知功能有关.
结论:
- 减少肠道排便频率与认知健康个体的认知功能受损有关.
- 肠道微生物失调症可能是肠道运动和认知健康之间的关键机械联系.
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