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Updated: Jul 15, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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在特定人群中预测药物代谢酶和载体活性变化的创新,机遇和挑战

Paresh P Chothe1, Vikram Arya2, Bhagwat Prasad2

  • 1Drug Metabolism and Pharmacokinetics, Oncology Research and Development, AstraZeneca, Waltham, Massachusetts (P.P.C., D.R.); Division of Infectious Disease Pharmacology, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland (V.A.); Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington (B.P.); and Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, R&D, Stevenage, United Kingdom (K.T.) paresh.chothe@astrazeneca.com.

Drug metabolism and disposition: the biological fate of chemicals
|September 29, 2023
PubMed
概括

药物代谢酶和载体 (DMETs) 研究的进展有助于药物开发. 然而,特定人群的有限数据阻碍了充分的潜力,需要进一步的研究和合作.

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