在肺移植手术中发生手术内血管综合征的发生率
Stephanie Lam1, Sean Mofidi1, Louis Saddic1
1Department of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA.
Journal of cardiothoracic and vascular anesthesia
|September 29, 2023
概括
血管综合征 (VS) 影响13.9%的肺移植患者,类似于心脏手术. 男性性别和囊性纤维化是肺移植后发展VS的重要危险因素.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 移植医学 移植医学
背景情况:
- 血管综合征 (VS),尽管心脏输出充足,但其特点是低血压和低系统血管抵抗,在心脏手术中很常见.
- 虽然在心脏外科手术中记录得很好,但在肺移植中对VS的发病率和风险因素的理解较少.
研究的目的:
- 为了确定肺移植受体中血管综合征 (VS) 的发生率.
- 在这个患者群体中识别与VS相关的风险因素.
- 探索与肺移植中的VS相关的结果.
主要方法:
- 追溯性研究包括2013年4月至2021年9月期间接受单次或双边肺移植的成年患者.
- 血管症综合征定义为平均动脉压<65 mmHg,心脏指数≥2.2 L/min/m2,以及血管压缩剂注射后≥30分钟.
- 统计分析包括t测试,曼·惠特尼U,奇方测试和多变量后勤回归来识别相关因素.
主要成果:
- 肺移植患者中血管综合征 (VS) 的发生率为13.9% (CI 10.4%-18.4%).
- 多变量分析确定男性性别 (OR 2.85) 和囊性纤维化 (OR 5.76) 作为VS的独立风险因素.
- 这项研究是在一家学术医院进行的.
结论:
- 肺移植中VS的发生率与心脏手术中观察到的发生率相当.
- 男性性别和囊性纤维化被确定为肺移植接受者的VS显著风险因素.
- 早期识别有风险的患者可能有助于预测和管理手术内并发症.
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