针对成年实体器官移植候选人的疫苗接种诊所的实施:单中心体验
Zitta Barrella Harboe1, Annemette Hald2, Christina Ekenberg3
1Department of Infectious Diseases, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Department of Pulmonary and Infectious Diseases, University Hospital of Copenhagen, North Zealand, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Vaccine
|September 29, 2023
概括
在实体器官移植 (SOT) 之前进行疫苗接种至关重要. 丹麦的一家诊所发现,所有SOT候选人都需要接种疫苗,大多数人需要多种疫苗,这凸显了移植前感染性疾病咨询的必要性.
科学领域:
- 移植医学 移植医学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 接种疫苗是预防固体器官移植 (SOT) 候选人的传染病 (ID) 的基石.
- 实施有针对性的疫苗接种策略对于在移植之前优化患者结果至关重要.
研究的目的:
- 描述SOT候选人的疫苗接种诊所的实施和结果.
- 评估移植前的血清保护率和记录的疫苗接种情况.
- 在咨询后评估疫苗接种完成率.
主要方法:
- 在丹麦的一个中心对242名SOT候选人的回顾性队列研究.
- 在ID咨询之前,对血清保护和记录的疫苗接种进行调查.
- 在ID咨询后完成疫苗接种的注册.
主要成果:
- 所有的SOT候选人至少需要一个疫苗;超过90%需要三种或更多.
- 流感疫苗和肺炎球菌疫苗在咨询前的记录率最低 (58%和37%).
- 对麻疹,疹和红疹的血清保护高 (~90%),但对于肺炎球菌疾病 (30%) 低.
- 咨询后观察到高度遵守疫苗接种计划,经常使用或推使用破伤风 - - 细胞性百日咳 (Tdap) 和肺炎球菌疫苗.
结论:
- 对于SOT候选人来说,强烈建议优先考虑通过专门的传染病咨询进行移植前疫苗接种.
- 疫苗接种诊所在固体器官移植前确保充分的免疫保护方面发挥着至关重要的作用.
- 在移植之前解决疫苗接种缺口可以提高患者的安全性和长期的移植成功.
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