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乳头甲状腺癌的侵袭性封装卵泡变体中的状结构结构:甲状腺实践中的陷
Sujata Yadav1, Devasenathipathy Kandasamy2, Nishikant Damle3
1Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Head and neck pathology
|September 29, 2023
概括
具有宏结构的乳头甲状腺癌的侵入性封装卵泡变体很少见,并且经常被错误诊断. 早期识别和了解其特征对于准确诊断和有效治疗至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 乳头甲状腺癌 (IEFVPTC-MF) 侵袭性封装毛囊变体的罕见表现显示出主要的宏毛囊结构.
- 这种特定的形态可能会导致在术前工作和组织病理学评估期间的误解.
研究的目的:
- 综合评估IEFVPTC-MF的放射学,细胞学,粗体,显微,分子和后续特征.
- 增加对这种罕见实体的认可,并为有限的现有文献做出贡献.
主要方法:
- 检索并审查了IEFVPTC-MF的四个经过病理学证明的病例.
- 分析了临床细节,甲状腺超声波,细胞学和甲状腺扫描结果.
- 进行了分子分析,包括PCR检测BRAF,KRAS,NRAS,HRAS突变和FISH检测ETV6::NTRK3和RET融合.
主要成果:
- 四例病例 (2男性,2女性,平均年龄27岁) 显示了各种超声波 (TR1-TR4) 和细胞学 (非诊断性,良性,AUS) 发现,通常与良性疾病重叠.
- 组织病理学揭示了带有伪毛囊的宏;分子分析确定了NRAS突变和ETV6::NTRK3融合,每例为1例.
- 两名患者发生了转移,放射性治疗后的反应从不完整到极佳.
结论:
- 在IEFVPTC-MF中,宏的结构构成了重大的诊断挑战,由于重叠的良性特征,往往导致诊断不足.
- 对这种实体的警理解对于准确的诊断至关重要,特别是考虑到远程转移的可能性和治疗反应的变化.
- 检测ETV6::NTRK3或其他融合为向治疗提供了潜力.
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