相关实验视频
Updated: Jul 15, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.7K
甲状腺功能低下症和低血症共存的团:一项基于全国人口的回顾性研究
Chun-Hao Chu1,2, Wu-Chien Chien3,4,5, Chiung-Chen Liu2
1Department of Pediatrics, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
BMC public health
|September 29, 2023
概括
甲状腺功能低下症和低血症在一起很少见,但它们的发病率正在上升. 老年,并发症和更长的住院时间显著预测了这些患者的死亡风险.
科学领域:
- 内分泌学和新陈代谢学
- 腎病學和泌尿病學.
- 老年医学 老年医学
背景情况:
- 甲状腺功能低下症是已知的,尽管很少见的,导致低甲状腺血的原因.
- 临床流行病学和相关的死亡风险 (ROM) 对于同时存在的甲状腺功能低下症和低甲状腺血量仍然不太了解.
研究的目的:
- 评估同时患有甲状腺功能低下症和甲状腺功能低下症的患者的流行病学.
- 为了评估这个患者队列的死亡风险 (ROM).
- 确定影响患有甲状腺功能低下症和甲状腺功能低下症同时存在的患者死亡率的因素.
主要方法:
- 使用台湾国家健康保险数据库 (1998-2015) 进行的回顾性队列研究.
- 对社会人口统计学因素,每年发病率和影响ROM的因素的分析.
- 评估逗留时间 (LOS) 作为死亡率的预测指标.
主要成果:
- 在4,549,226名总患者中,分析了3,140名同时存在甲状腺功能低下和低血症的索引患者.
- 从1998年到2015年,发病率增加了十倍;年平均发病率为174.
- 老年 (>55岁),灾难性疾病,心脏节律失常和医院等级是死亡率的独立预测因素. 一个LOS>16天增加了ROM的2.3倍.
结论:
- 同时存在的甲状腺功能低下症和低血是罕见的,但越来越多的疾病.
- 影响死亡率的关键因素包括老年,严重的并发病,心脏问题,医院护理水平和长时间住院.
- 临床护理应考虑这些因素,以改善患者的治疗结果.
相关概念视频
Hypertension III: Clinical Manifestations and Diagnostic Studies
23
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
23
Antihypertensive Drugs: Potassium-Sparing Diuretics
612
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
612
Renal Tubule and Collecting Duct
1.1K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
1.1K
Disorder of Water Balance
440
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
440
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Physiology of the Genitourinary System III: Urine Concentration and Dilution
19
The kidneys concentrate or dilute urine to maintain water and electrolyte balance. Nephrons, particularly the loop of Henle, play a crucial role in this process through the countercurrent multiplication system. This system establishes a high osmolarity in the renal medulla, which is essential for water reabsorption. In the loop of Henle’s descending limb, water is reabsorbed into the surrounding medulla due to its permeability to water. In contrast, the ascending limb actively transports...
19

