在儿童中Acinetobacter Baumannii细菌病的预后初步指标
Yi Hong1,2, Xiaochen Lin1, Chunxu Zhang1
1Pediatric Intensive Care Unit, Children Hospital of Soochow University, Suzhou, Jiangsu, China.
BMC infectious diseases
|September 29, 2023
概括
Acinetobacter baumannii (AB) 细菌病在儿童中具有很高的死亡率,特别是那些患有血液学或瘤学疾病的儿童. 升高的C-反应蛋白 (CRP) 和中性质衰竭是儿科AB细菌血症预后不佳的关键早期指标.
科学领域:
- 儿童传染病 儿童传染病
- 临床微生物学 临床微生物学
- 关键护理医学 关键护理医学
背景情况:
- 在住院儿童中,Acinetobacter baumannii (AB) 细菌病具有显著的死亡风险.
- 之前的研究已经确定了AB细菌病死亡率的一般风险因素,但早期预后指标仍未得到充分研究.
研究的目的:
- 调查早期临床表现并确定实验室确认的AB细菌血症儿童死亡率的独立预测因素.
- 分析与儿科AB细菌病的结果相关的人口,临床和实验室特征.
主要方法:
- 在中国苏州,对37名住院儿童进行了回顾性分析,这些儿童患有确诊的AB细菌病.
- 收集的数据包括人口统计,临床特征,抗生素敏感性和结果.
- 使用多变量分析来确定死亡率的独立风险因素.
主要成果:
- 总体死亡率为48.65% (18/37). 这是一个非常严重的疾病.
- 在未幸存者中观察到更高的呼吸衰竭,休克,MODS和中性衰竭的发病率.
- 感染后24小时内增加的C-反应蛋白 (CRP) 和中性衰竭被确定为死亡率的独立预测因素.
- CRP水平>59.02 mg/L和中性质衰竭显示出高灵敏度和特异性来预测死亡率.
结论:
- 青杆菌 (Acinetobacter baumannii) 细菌病在儿科患者中具有很高的死亡风险,特别是那些患有血液学和瘤学疾病的患者.
- 升高的CRP和中性衰竭的存在是AB细菌血症儿童30天死亡率的显著早期预测因素.
相关概念视频
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
15
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
15
01:30Pneumonia III: Complications and Assessment
253
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
253
01:27Acute Pyelonephritis I: Introduction
20
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
20