血清HMGB1是急性心肌梗塞与心力衰竭或没有心力衰竭的生物标志物
Abdul Wahid1, Juan Wen1, Qiong Yang1
1Department of Cardiology of the Third Xiang-Ya Hospital, Central South University, Changsha, Hunan, China.
Clinical and translational science
|September 30, 2023
概括
血清高流动性组盒1 (HMGB1) 在急性心肌梗塞 (AMI) 和心力衰竭 (HF) 患者中升高. HMGB1与炎症和心脏生物标志物相关,特别是在高血压的AMI中,突出了它在心血管疾病中的作用.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生化学
- 炎症研究 炎症研究
背景情况:
- 高流动性组第1框 (HMGB1) 与炎症过程有关.
- 在急性心肌梗塞 (AMI) 和心力衰竭 (HF) 中HMGB1的作用及其与心脏和炎症生物标志物的相关性需要进一步研究.
研究的目的:
- 在AMI和/或HF患者中测量血清HMGB1水平.
- 在这些患者群体中评估HMGB1和外周炎症和心脏生物标志物之间的关系.
- 探索HMGB1和心血管风险因素之间的相关性.
主要方法:
- 血清HMGB1水平测量了55名没有HF的AMI患者,42名AMI和HF患者,60名没有AMI的HF患者和50名健康对照患者.
- 评估了炎症生物标志物 (ESR,hs-CRP,尿酸,WBC) 和心脏生物标志物 (MYO,cTnI,CKMB,CK,NT-proBNP,LDH,AST,ALT) 的使用情况.
- 进行了统计分析,以确定HMGB1,生物标志物和风险因素之间的相关性.
主要成果:
- 与对照组相比,所有患者组的血清HMGB1水平都显著升高,最显著的是HF的AMI.
- 在AMI患者中,HMGB1与大多数炎症生物标志物 (尿酸除外) 有显著的正相关性.
- 在AMI患者中,心脏生物标志物通常升高. 在所有患者中,HMGB1与NT-proBNP和cTnI显著相关,在AMI组中与大多数心脏生物标志物相关.
- 高血压,糖尿病,先前的心脏病和减少的射出分数与HMGB1水平相关.
结论:
- 血清HMGB1是AMI和HF的潜在生物标志物,反映了疾病严重程度和炎症状态.
- HMGB1水平与关键的炎症和心脏损伤标志物相关,这表明它参与了这些疾病的病理生理学.
- HMGB1可以作为评估心血管风险和疾病进展的有价值指标.
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