吸入氧化测试在预测由于左侧心脏病导致的肺高血压的预后
Taijyu Satoh1, Nobuhiro Yaoita1, Kotaro Nochioka1
1Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
ESC heart failure
|September 30, 2023
概括
吸入氧化 (NO) 测试对于由于心脏左侧疾病导致的肺高血压 (PH) 患者是安全的. 在NO吸入后肺动脉压 (PAWP) 的变化预测了2组PH患者的结果.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由左侧心脏病 (组2PH) 引起的肺高血压 (PH) 具有独特的病理生理学.
- 目前的治疗方法并没有选择性地针对2组PH的肺循环.
- 氧化物 (NO) 溶解的酸环酶-环素单酸盐通路涉及到2组PH.
研究的目的:
- 在2组PH中调查吸入NO的血管活性测试的实用性.
- 为了确定NO吸入后肺动脉压 (PAWP) 的变化是否具有预后价值.
主要方法:
- 对69名2组PH患者进行了回顾性单中心研究 (2011年1月至2015年12月).
- 患者接受了吸入NO测试.
- 随访时间中位数为365天;评估结果是全因死亡或因心力衰竭 (HF) 入院.
主要成果:
- 吸入NO的耐受性很好,没有任何不良事件.
- 在NO吸入后,34名患者表现出增加的PAWP (ΔPAWP:3.26 ± 2.22 mmHg).
- 多变量分析发现,增加的PAWP是1年死亡率或HF住院的唯一显著预测因素 (HR 4.35;P=0.019).
结论:
- 吸入NO测试在2组PH患者中是安全的和可行的.
- NO诱导的PAWP变化是2组PH的新预后指标.
- 对NO的反应在心力衰竭与保留和减少的喷射分数之间有所不同.
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
207
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
207
Mitral Stenosis II: Clinical features and Diagnostic Tests
22
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
22
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
249
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
249


