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Updated: Jul 15, 2025

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基于CYP2C19表型的克洛皮多格勒的群体药理动力学-药理动力学建模,以优化基于CYP2C19表型的剂量方案:概念验证研究

Yun Seob Jung1, Byung Hak Jin2, Min Soo Park2,3

  • 1Department of Convergence Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

CPT: pharmacometrics & systems pharmacology
|September 30, 2023
PubMed
概括

人口的药理动力学-药理动力学建模可以个性化克洛皮多格雷尔剂量. 较差的CYP2C19代谢器和高基线P2Y12反应单元需要显著更高的剂量才能产生有效的抗血小板作用.

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