超膜近红外光刺激对老年人大脑功能连接和认知的剂量反应 - 一个随机比较
Himanshu Joshi1,2, Preeti Sinha2,3, Dawn Bowers4,5
1Multimodal Brain Image Analysis Laboratory, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Journal of biophotonics
|September 30, 2023
概括
高剂量的光生物调制 (PBM) 在老年人中显著改善了认知功能和大脑连接. 这表明近红外光 (NIRL) 可能为神经退行性疾病提供未来的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 光生物调制 (PBM),或低水平光疗法,在动物模型中显示出增强大脑活动和认知能力的前景.
- 人类研究PBM对认知,大脑功能连接和最佳剂量的影响是有限的.
研究的目的:
- 研究近红外 (NIR) PBM对健康老年人认知功能和休息状态大脑功能连接的剂量依赖性影响.
- 为了确定特定的NIR光剂量是否可以调节大脑活动并改善认知表现.
主要方法:
- 25名认知正常的成年人 (年龄在55-70岁) 被随机分为三个组:假的,低剂量的NIR PBM (26 J/cm2跨,9 J/cm2鼻内) 和高剂量的NIR PBM (52 J/cm2跨,18 J/cm2鼻内).
- 认知功能和休息状态的功能连接性在一次PBM会话后被评估.
主要成果:
- 与假装组相比,高剂量的NIR PBM组显示左上额头 (SFG) 和左平面 (PT) (p=0.0016),以及左下额头 (p=0.0235) 之间的静止状态功能连接显著增加.
- 在高剂量组 (p=0.012) 中,观察到视觉搜索和处理速度的显著改善.
结论:
- 高剂量的跨和鼻内NIR PBM可以增强健康老年人的特定大脑功能连接和认知处理速度.
- 这些发现支持进一步研究NIR PBM,作为一种潜在的非侵入性治疗方法,用于认知衰退和神经退行性疾病,如阿尔茨海默病.
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