在慢性病中,血管化的未来治疗方法
Mario Cozzolino1, Federico Maffei Faccioli1, Anila Cara1
1Renal Division, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.
Expert opinion on pharmacotherapy
|September 30, 2023
概括
慢性病 (CKD) 患者的血管化 (VC) 导致心血管疾病 (CVD). 本综述详细介绍了VC病理生理学,生物标志物和当前/新兴治疗方法,以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 血管生物学 血管生物学
背景情况:
- 心血管疾病 (CVD) 是慢性病 (CKD) 患者的主要死亡原因.
- 血管化 (VC) 在CKD中显著推动心血管疾病,这是由复杂的分子相互作用引起的.
- 病理性VC涉及内皮功能障碍,氧化应激,炎症和改变的矿化抑制剂.
研究的目的:
- 审查慢性病 (CKD) 中血管化 (VC) 的病理生理学.
- 总结目前的VC生物标志物.
- 专注于CKD患者VC的现有和新型治疗策略.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 对VC病理生理学现有研究的综合.
- 对当前和实验性治疗方法的分析.
主要成果:
- VC是由化促进剂和抑制剂的不平衡引起的.
- 对VC的生物标志物正在调查中.
- 目前的治疗方法侧重于矿物质平衡,维生素缺乏,骨循环和炎症.
结论:
- 针对细胞机制和开发预测得分对于管理VC至关重要.
- 需要改进治疗策略,以减少心血管疾病发病率和CKD死亡率.
- 早期检测和向治疗对于更好的患者管理至关重要.
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