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梅特福林改善了FGF21信号的先决条件,用于2型糖尿病患者

Anne Kathrine Nissen Pedersen1, Lars Christian Gormsen2, Søren Nielsen3,4

  • 1Medical/Steno Aarhus Research Laboratory, Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark.

The Journal of clinical endocrinology and metabolism
|September 30, 2023
PubMed
概括

在2型糖尿病患者中,甲福明治疗降低了纤维细胞激活蛋白 (FAP) 的活性,并通过调节FGFR1c和β-klotho来增强脂肪组织中的FGF21信号传递. 这表明,随着甲福林治疗,外围FGF21敏感性得到改善.

关键词:
纤维细胞激活蛋白 (FAP) 是一种激活蛋白.纤维细胞生长因子21 (FGF21)甲胺是一种甲胺.第二种类型糖尿病 (T2D)

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