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微RNA和结直肠癌:临床潜力和监管网络

George Yiadom Osei^1,2, Joseph Adu-Amankwaah³, Selina Koomson²

¹Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, 13200, Malaysia.

Molecular biology reports

|September 30, 2023

概括

结肠直肠癌 (CRC) 治疗耐药性是一个重大挑战. 本综述探讨了microRNAs (miRNAs) 在CRC中的作用及其对新型向疗法的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

结肠直肠癌 (CRC) 是一个严重的全球健康负担,发病率和死亡率很高.
尽管在早期检测和治疗方面取得了进展,但治疗耐药性仍然是CRC管理中的一个常见障碍.
微RNAs (miRNAs),调节基因表达的小型非编码RNAs,越来越多地被认为在CRC启动和进展中的关键作用.

研究的目的:

为了提供一个全面的概述miRNAs在结直肠癌致癌的参与.
确定现有CRC治疗策略中的当前挑战和局限性.
探索基于miRNA治疗结直肠癌的治疗潜力.

主要方法:

文献综述侧重于微RNAs在结直肠癌中的作用.
分析当前的治疗策略及其局限性.
探索新兴的miRNA向疗法.

主要成果:

微RNA是驱动结直肠癌发展和进展的复杂分子机制的组成部分.
特定miRNAs的失调有助于CRC治疗耐药性.
针对性调节miRNA功能为新型CRC治疗提供了一个有希望的途径.

结论:

微RNA是结直肠癌的关键调节剂,并代表了可行的治疗点.
了解miRNA路径可以改善CRC的诊断和治疗策略.
基于MiRNA的疗法具有克服治疗耐药性和改善结直肠癌患者治疗结果的巨大潜力.

关键词:

结肠直肠癌是一种癌症.治疗目标是治疗的目标.微RNAs 是一个微型RNA.

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...