毒素注射是否会在脑患者中加剧肉类和骨质?
Yu-Chi Su1, Meng-Che Tsai2, Chung-Ying Lin3
1Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Pediatric neurology
|September 30, 2023
概括
毒素 (BoNT) 在患有性脑 (CP) 的儿童和青少年中没有加剧症或低骨质量. 注射肢体的肌肉质量增加,但握力和骨密度在24周内保持不变.
科学领域:
- 儿科整形外科 儿科整形外科
- 神经肌肉疾病 神经肌肉疾病
- 康复医学 康复医学 康复医学
背景情况:
- 已知毒素 (BoNT) 在动物模型中会导致肉症和低骨质量.
- 儿童性脑 (CP) 中BoNT对骨和肌肉健康的影响尚未得到充分证实.
- 研究这些影响对于管理这一群体的长期健康至关重要.
研究的目的:
- 确定BoNT对抓力 (GS),骨肌肉质量和骨矿物质密度 (BMD) 在患有性CP的儿童和青少年中的影响.
- 评估BoNT是否会在这个特定的患者群体中加剧肉症或低骨质量.
主要方法:
- 进行了一项不受控制的纵向研究,25名参与者 (平均年龄8.5岁) 患有性CP.
- 在BoNT干预之前和24周后,使用双能量X射线吸收计测量身体组成,包括骨肌肉质量和BMD.
- 萨科佩尼亚是由减少的GS和低肌肉质量的存在来定义的.
主要成果:
- 在24周的随访期间,注射肢体的骨肌肉质量和尾肌肉质量显著增加 (P < 0.05).
- 总体减去头部 BMD 也显示显著增加 (P = 0.0229).
- 在研究期间,握力的强度,肉症的患病率和低骨质量的患病率没有显著变化.
结论:
- 博毒素 (BoNT) 的干预似乎不会加剧儿童和青少年的性脑膜炎的萨尔科佩尼亚或低骨质量.
- 虽然BoNT可能会对治疗肢体的肌肉质量产生积极影响,但它对握力和整体骨密度的影响需要进一步调查.
- 这些发现表明BoNT在儿科CP患者的骨和肌肉健康方面具有潜在的安全特征.
相关概念视频
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
698
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
698
01:21Skeletal Muscle Relaxants: Adverse Effects
393
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
393
01:26Cross-bridge Cycle
117.6K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
117.6K
01:31Skeletal Muscle Relaxants: Therapeutic Uses
506
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
506