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Updated: Jul 31, 2026

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小分子屏幕识别了pyrimethamine作为NRF2驱动的食道增生抑制剂

Chorlada Paiboonrungruang1, Zhaohui Xiong1, David Lamson2

  • 1Coriell Institute for Medical Research, Camden, NJ, 08103, USA; Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, 27707, USA.

Redox biology
|September 30, 2023
PubMed
概括

研究人员将pyrimethamine确定为一种新型的核因子红色素2相关因子2 (NRF2) 抑制剂. 这种化合物有效向NRF2激活的食道状细胞癌 (ESCC),并显示出临床测试的前景.

关键词:
食管状细胞癌的癌症这就是 KEAP1 的特点.米托克桑特龙是什么意思?这就是NRF2的NRF2.皮里米他胺是一种甲胺.

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