口腔真菌分析和鼻癌的风险:一个基于人口的病例控制研究
Yufeng Chen1, Wanxin Li2, Ellen T Chang3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
EBioMedicine
|September 30, 2023
概括
减少口腔真菌多样性和特定的真菌过度生长与增加鼻癌 (NPC) 风险有关. 这项研究突出了口腔真菌生物组.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 人类健康 人类健康 人类健康
背景情况:
- 口腔真菌生物组失生症与各种疾病有关.
- 口腔真菌在鼻癌 (NPC) 发展中的特定作用以前是未知的.
研究的目的:
- 调查口腔真菌生物组与鼻癌 (NPC) 风险之间的关联.
- 描述NPC患者和健康对照中的真菌群体.
主要方法:
- 用真菌内部转录间隔器 (ITS) -2 测序来分析口腔唾液菌群.
- 包括476名未经治疗的NPC患者和537名基于人口的对照.
- 使用生物信息和生物统计分析来评估菌群和NPC风险之间的关系.
主要成果:
- 较低的真菌α多样性与显著更高的NPC发展几率相关.
- 在NPC病例和对照之间观察到不同的全球真菌社区模式.
- 包括Saccharomyces cerevisiae,Candida tropicalis和Candida albicans在内的特定真菌与NPC概率的增加有关.
结论:
- 口腔真菌生物组失生症,标志着真菌多样性减少和某些物种过度生长,与NPC的风险大幅增加有关.
- 这些发现表明,口腔真菌生物组是NPC致癌的潜在因素.
更多相关视频
09:52Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
10.6K
15:01Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung
Published on: September 18, 2021
3.4K
相关概念视频
Fungal Phylum Ascomycota
35
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
35
Fungal Phylum Microsporidia
37
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
37
Fungal Group Zygomycota
37
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
37
