基于N-异环碳素的双核有机化合物与它们的配体相比,具有温和的生物杀伤潜力:合成,表征,计算研究
Ahmad Hassan1, Muhammad Adnan Iqbal1, Haq Nawaz Bhatti2
1Department of Chemistry, University of Agriculture Faisalabad, Faisalabad, Pakistan; Organometallic and Coordination Chemistry Laboratory, University of Agriculture Faisalabad, Faisalabad 38040, Pakistan.
Computational biology and chemistry
|September 30, 2023
概括
新的N-异环碳 (NHC) 化合物及其添加物显示出有前途的抗微生物和抗氧化活性. 亚盐具有较低的毒性,这表明在体内研究的潜力.
科学领域:
- 药用化学 医学化学
- 有机金属化学 有机金属化学
- 计算化学计算化学
背景情况:
- N-异环碳化合物 (NHC) 具有显著的生物潜力.
- 与金属中心的协调可以提高基于NHC的化合物的疗效.
研究的目的:
- 合成和描述新型双核盐及其添加物.
- 评估合成化合物的抗微生物和抗氧化特性.
- 通过血溶性测试来评估化合物的毒性.
主要方法:
- 三种双核盐 (L1-L3) 和它们的添加物 (L1Se-L3Se) 的合成.
- 使用分析技术和计算模拟进行表征.
- 对抗S. Aureus和E. Coli的抗菌活性进行查.
- 通过DPPH激素清除试验评估抗氧化活性.
- 确定针对红细胞的血溶性毒性.
主要成果:
- 合成的化合物通过分析和计算方法得到证实.
- 化合物显示出显著的抗微生物活性,对抗阳性 (S.Aureus) 和阴性 (E.Coli) 细菌.
- 与其添加物 (IC50: 9.50-12.75 μg/mL) 相比,阿佐盐表现出更高的抗氧化潜力 (IC50: 5.75-6.55 μg/mL).
- 与它们的Se-添加物相比,联体在溶血试验中显示出较低的毒性.
结论:
- 合成的以NHC为基础的盐及其添加物具有显著的抗微生物和抗氧化特性.
- 酸盐的毒性低于酸盐,这表明它们适合进行进一步的体内研究.
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