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在出生后对SARS-CoV-2的粘膜和全身免疫力的多组分析

Florian Wimmers¹, Allison R Burrell², Yupeng Feng³

¹Department of Molecular Medicine, Interfaculty Institute for Biochemistry, University of Tuebingen, 72076 Tuebingen, Baden-Wuerttemberg, Germany; DFG Cluster of Excellence 2180 "Image-guided and Functional Instructed Tumor Therapy" (iFIT), University of Tuebingen, 72076 Tuebingen, Baden-Wuerttemberg, Germany; German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Baden-Wuerttemberg, Germany.

|September 30, 2023

概括

婴儿与成年人不同,对SARS-CoV-2产生持久免疫力. 它们强大的粘膜和血液免疫反应,包括高抗体标位,在感染后至少持续300天.

科学领域:

免疫学
病毒学
儿童医学

背景情况:

婴儿对严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 的免疫力尚不清楚.
了解婴儿免疫反应对于公共卫生策略至关重要.

研究的目的:

对婴儿和幼儿的SARS-CoV-2免疫力进行纵向分析.
为了比较这个年龄组对Omicron和非Omicron变异的免疫反应.

主要方法:

在SARS-CoV-2感染之前,感染期间和感染后,对婴儿的血液和鼻腔抽样进行多组分析.
在最多300天的时间内进行纵向采样.
单细胞多组学分析骨髓细胞中的基因表达.

主要成果:

婴儿表现出强大而持久的抗体标位,在长达300天的时间内没有观察到衰变.
具有强烈的粘膜免疫反应的特征是炎症性细胞因子,干扰素 (IFN) α,T助手 (Th) 17和中性粒细胞标记物 (干扰素[IL]-17,IL-8和CXCL1).
血液免疫反应显示出先天细胞激活,化学因子和IFNα,与病毒载量和干扰素刺激基因 (ISG) 相相关.

结论:

婴儿对SARS-CoV-2感染产生独特而持久的免疫反应.
这些发现提供了关于病毒感染后早期免疫力学的见解.
这项研究提供了婴儿生命最初几周和几个月免疫力的快照.

关键词:

冠状病毒耐久性婴儿粘膜免疫力多种类型新生儿一个细胞的ATAC-seq 一个细胞RNA-seq 病毒感染

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