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开始性细菌对铁的获取会在沙门氏菌感染期间改变宿主营养免疫力
Luisella Spiga1, Ryan T Fansler1, Yasiru R Perera2
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Cell host & microbe
|September 30, 2023
概括
肠道细菌如 Bacteroides thetaiotaomicron 使用来自其他微生物的 siderophores,如沙门氏菌,在肠道炎症期间获得铁. 这种开始性铁获取会影响宿主的营养免疫力和病原体逃避策略.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 宿主营养免疫力在肠道炎症期间限制微生物铁的获取.
- 病原体使用诸如肠杆菌素这样的 siderophores 吸收铁,而宿主 lipocalin-2.calin 对抗它们.
- 开始性细菌在铁介导营养免疫中的作用在很大程度上是未知的.
研究的目的:
- 为了研究共生细菌,特别是 Bacteroides thetaiotaomicron,如何在炎症的肠道中获得铁.
- 探索共生动物与宿主营养免疫和病原体铁获取策略相互作用的机制.
主要方法:
- 研究了使用 siderophores 的 Bacteroides thetaiotaomicron 获得铁的情况.
- 描述了分泌的 siderophore 结合性脂蛋白 XusB. 的功能.
- 评估了XusB对肠杆菌素对宿主利波卡林-2和沙门氏菌再获取能力的影响.
主要成果:
- 细菌菌体 (Bacteroides thetaiotaomicron) 使用细菌的 siderophores,包括肠杆菌素,在炎症的肠道中获取铁.
- 该XusB脂蛋白促进共体铁的吸收,并降低了肠杆菌素对宿主利波卡林-2的敏感性.
- 沙门氏菌可以重新获得与XusB结合的肠杆菌素,使病原体能够逃避宿主营养免疫力.
结论:
- 由XusB介导的体内铁代谢是肠道炎症期间宿主-病原体相互作用的新型因素.
- 进食者利用细菌的 siderophore 影响了肠道微生物群内的铁竞争的动态.
- 这项研究突出了以前未知的调节宿主营养免疫力和病原体生存的机制.
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