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含有Isoliquiritigenin的PH敏感小胞,可以增强抗结肠炎活性
Feng Shi1, Mengzhe Du2, Qin Wang2
1Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, Jiangsu, CN, PR China; Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Zhenjiang, CN, PR China.
这项研究开发了Isoliquiritigenin (ISL) 的pH敏感 (ISL-M) 来增强ISL.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 伊索利基基因因 (ISL) 具有多种不同的药理活动.
- 由于ISL的水溶性较差,因此限制了其生物可用性和治疗效果.
- 开发先进的药物输送系统对于改善ISL的应用至关重要.
研究的目的:
- 为增强药物递送提供IsoliquiritigeninpH敏感小粒 (ISL-M) 的配方.
- 评估ISL-M.的物理化学特性,稳定性和体外释放.
- 评估ISL-M的体内药理动力学和抗结肠炎功效.
主要方法:
- 通过薄膜水化方法制备ISL-M.
- 描述包括细胞大小,PDI,泽塔潜力,药物负载和封装效率.
- 进行了体外释放研究,稳定性测试,大鼠的药物动力学分析和抗炎性评估.
主要成果:
- ISL-M表现出有利的特征:大小 (151.15 nm),PDI (0.092),泽塔电位 (-31.32 mV),EE% (93.97%) 和DL% (8.42%).
- 与未配制的ISL相比,ISL-M显示了pH敏感释放,并显著增加了累积释放率.
- 药理动力学研究显示,与ISL相比,ISL-M的AUC (0-t) 增加了2.94倍,Cmax增加了4.06倍.
结论:
- ISL-M配方有效地提高了Isoliquiritigenin的生物可用性.
- 发育的菌体显示出有希望的pH敏感释放和增强的抗炎活性.
- ISL-M 是一种可行的策略,可以提高ISL的治疗潜力,特别是对于结肠炎的治疗.
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